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KMID : 1134820180470010001
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Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 1 p.1 ~ p.6
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Immunomodulatory Effects of Arginine-Fructose-Glucose Enriched Extracts of Red Ginseng
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Hyun Sun-Hee
Kim Young-Sook
Lee Jong-Won
Han Chang-Kyun
Park Min-Seon
So Seung-Ho
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Abstract
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The purpose of this study was to investigate the immuno-modulatory effects of arginine-fructose-glucose (AFG)-enriched extracts of red ginseng. The effect on proliferation in normal mouse splenocytes was measured in vitro. When mouse splenocytes were exposed to various concentrations of AFG-enriched extracts with mitogens (concanavalin A, lipopolysaccharide), splenocyte proliferation significantly increased. In vivo, AFG-enriched extracts were orally administered (250, 500, and 1,000 mg/kg/d for 10 days) with cyclophosphamide (CY, 50 mg/kg, i.p.) to male balb/c mice, which were sensitized with sheep red blood cells (SRBCs) to measure the number of IgM antibody-forming cells in splenocytes. AFG-enriched extracts restored the weights of the spleen and thymus, which were reduced by CY. AFC counts per million splenocytes and total splenocyte number significantly increased in a dose-dependent manner compared with the CY Control group. These results indicate that AFG-enriched extracts increased humoral immunity against CY-induced immunosuppression in animal models.
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KEYWORD
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arginine-fructose-glucose (AFG), antibody forming cells, splenocyte proliferation, cyclophosphamide
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